Opening up connectivity between documents, structures and bioactivity.

Bioscientists studying papers or patents try to discern the important thing relationships reported inside a doc “D” the place a bioactivity “A” with a quantitative consequence “R” (e.g., an IC50) is reported for chemical construction “C” that modulates (e.g., inhibits) a protein goal “P”. A helpful shorthand for this connectivity thus turns into DARCP.

The downside on the core of this text is that the neighborhood has spent tens of millions successfully burying these relationships in PDFs over many a long time however should now spend tens of millions extra attempting to get them again out. The key crucial for that is to extend the circulation into structured open databases.

The constructive impacts will embrace expanded information mining alternatives for drug discovery and chemical biology. Over the final decade industrial sources have manually extracted DARCP from ≈300,000 paperwork encompassing ≈7 million compounds interacting with ≈10,000 targets. Over an analogous time, the Guide to Pharmacology, BindingDB and ChEMBL have carried out analogues DARCP extractions. Although their expert-curated numbers are decrease (i.e., ≈2 million compounds towards ≈3700 human proteins), these open sources have the good benefit of being merged inside PubChem. Parallel efforts have centered on the extraction of document-to-compound (D-C-only) connectivity.

In the absence of molecular mechanism of motion (mmoa) annotation, that is of much less worth however could be mechanically extracted. This has been considerably completed for patents, (e.g., by IBM, SureChEMBL and WIPO) for over 30 million compounds in PubChem. These have just lately been joined by 1.four million D-C submissions from three main chemistry publishers. In addition, each the European and US PubMed Central portals now add chemistry look-ups from abstracts and full-text papers. However, the absolutely automated extraction of DARCLP has not but been achieved.

Opening up connectivity between documents, structures and bioactivity.
Opening up connectivity between documents, structures and bioactivity.

This stands in distinction to the power of biocurators to discern these relationships in minutes. Unfortunately, no journals have but instigated a circulation of author-specified DARCP immediately into open databases. Progress might come from developments equivalent to open science, open entry (OA), findable, accessible, interoperable and reusable (FAIR), useful resource description framework (RDF) and WikiData. However, we might want to await the technical applicability in respect to DARCP seize to see if this opens up connectivity.

Dbil5 (untagged ORF) - Rat diazepam binding inhibitor-like 5 (Dbil5), (10 ug)

RN213689 10 µg Ask for price

DBIL5 siRNA

20-abx913597
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  • 15 nmol
  • 30 nmol

DBIL5 siRNA

20-abx913598
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  • 15 nmol
  • 30 nmol

Dbil5 (GFP-tagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5)

MG200199 10 µg Ask for price

Dbil5 (untagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5), (10ug)

MC204899 10 µg Ask for price

Dbil5 (Myc-DDK-tagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5)

MR200199 10 µg Ask for price

Dbil5 (Myc-DDK-tagged ORF) - Rat diazepam binding inhibitor-like 5 (Dbil5), (10 ug)

RR213689 10 µg Ask for price

Lenti ORF particles, Dbil5 (GFP-tagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5), 200ul, >10^7 TU/mL

MR200199L4V 200 µl Ask for price

Lenti ORF particles, Dbil5 (GFP-tagged ORF) - Rat diazepam binding inhibitor-like 5 (Dbil5), 200ul, >10^7 TU/mL

RR213689L4V 200 µl Ask for price

Lenti ORF particles, Dbil5 (Myc-DDK-tagged ORF) - Rat diazepam binding inhibitor-like 5 (Dbil5), 200ul, >10^7 TU/mL

RR213689L3V 200 µl Ask for price

Lenti ORF clone of Dbil5 (mGFP-tagged ORF) - Rat diazepam binding inhibitor-like 5 (Dbil5), (10 ug)

RR213689L4 10 µg Ask for price

Lenti ORF particles, Dbil5 (Myc-DDK-tagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5), 200ul, >10^7 TU/mL

MR200199L3V 200 µl Ask for price

Lenti ORF clone of Dbil5 (mGFP-tagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5)

MR200199L4 10 µg Ask for price

Lenti ORF clone of Dbil5 (Myc-DDK-tagged ORF) - Rat diazepam binding inhibitor-like 5 (Dbil5), (10 ug)

RR213689L3 10 µg Ask for price

Dbil5 ORF Vector (Rat) (pORF)

ORF065789 1.0 ug DNA
EUR 607.2

Lenti ORF clone of Dbil5 (Myc-DDK-tagged) - Mouse diazepam binding inhibitor-like 5 (Dbil5)

MR200199L3 10 µg Ask for price

Rat DBIL5 shRNA Plasmid

20-abx985979
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  • 150 µg
  • 300 µg

Dbil5 ORF Vector (Mouse) (pORF)

ORF042638 1.0 ug DNA
EUR 607.2

Dbil5 3'UTR GFP Stable Cell Line

TU154862 1.0 ml Ask for price

Dbil5 3'UTR GFP Stable Cell Line

TU253164 1.0 ml Ask for price

Mouse DBIL5 shRNA Plasmid

20-abx969951
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  • 150 µg
  • 300 µg

DBIL5P ORF Vector (Human) (pORF)

ORF018054 1.0 ug DNA Ask for price

DBIL5P2 ORF Vector (Human) (pORF)

ORF018055 1.0 ug DNA Ask for price

Recombinant mouse DBIL5

P2064 100ug Ask for price
Description: Recombinant protein for mouse DBIL5

Dbil5 Protein Vector (Rat) (pPM-C-HA)

PV263156 500 ng
EUR 723.6

Dbil5 Protein Vector (Rat) (pPB-C-His)

PV263154 500 ng
EUR 723.6

Dbil5 Protein Vector (Rat) (pPB-N-His)

PV263155 500 ng
EUR 723.6

Dbil5 Protein Vector (Rat) (pPM-C-His)

PV263157 500 ng
EUR 723.6

Dbil5 Protein Vector (Mouse) (pPM-C-HA)

PV170552 500 ng
EUR 723.6

Dbil5 Protein Vector (Mouse) (pPB-C-His)

PV170550 500 ng
EUR 723.6

Dbil5 Protein Vector (Mouse) (pPB-N-His)

PV170551 500 ng
EUR 723.6

Dbil5 Protein Vector (Mouse) (pPM-C-His)

PV170553 500 ng
EUR 723.6

Dbil5 3'UTR Luciferase Stable Cell Line

TU104862 1.0 ml Ask for price

Dbil5 3'UTR Luciferase Stable Cell Line

TU203164 1.0 ml Ask for price

Dbil5 sgRNA CRISPR Lentivector set (Rat)

K6901901 3 x 1.0 ug
EUR 406.8

DBIL1 sgRNA CRISPR Lentivector set (Human)

K0562801 3 x 1.0 ug
EUR 406.8

DBIL2 sgRNA CRISPR Lentivector set (Human)

K0562901 3 x 1.0 ug
EUR 406.8

DBIL3 sgRNA CRISPR Lentivector set (Human)

K0563001 3 x 1.0 ug
EUR 406.8

DBIL4 sgRNA CRISPR Lentivector set (Human)

K0563101 3 x 1.0 ug
EUR 406.8

Dbil5 sgRNA CRISPR Lentivector set (Mouse)

K4706901 3 x 1.0 ug
EUR 406.8

Dbil5 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6901902 1.0 ug DNA
EUR 184.8

Dbil5 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6901903 1.0 ug DNA
EUR 184.8

Dbil5 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6901904 1.0 ug DNA
EUR 184.8

Dbil5 (Rat) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR513400 2 nmol Ask for price

Dbil5 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each

SR400679 2 nmol Ask for price

DBIL1 sgRNA CRISPR Lentivector (Human) (Target 1)

K0562802 1.0 ug DNA
EUR 184.8

DBIL1 sgRNA CRISPR Lentivector (Human) (Target 2)

K0562803 1.0 ug DNA
EUR 184.8

DBIL1 sgRNA CRISPR Lentivector (Human) (Target 3)

K0562804 1.0 ug DNA
EUR 184.8

DBIL2 sgRNA CRISPR Lentivector (Human) (Target 1)

K0562902 1.0 ug DNA
EUR 184.8

DBIL2 sgRNA CRISPR Lentivector (Human) (Target 2)

K0562903 1.0 ug DNA
EUR 184.8

DBIL2 sgRNA CRISPR Lentivector (Human) (Target 3)

K0562904 1.0 ug DNA
EUR 184.8

DBIL3 sgRNA CRISPR Lentivector (Human) (Target 1)

K0563002 1.0 ug DNA
EUR 184.8

DBIL3 sgRNA CRISPR Lentivector (Human) (Target 2)

K0563003 1.0 ug DNA
EUR 184.8

DBIL3 sgRNA CRISPR Lentivector (Human) (Target 3)

K0563004 1.0 ug DNA
EUR 184.8

DBIL4 sgRNA CRISPR Lentivector (Human) (Target 1)

K0563102 1.0 ug DNA
EUR 184.8

DBIL4 sgRNA CRISPR Lentivector (Human) (Target 2)

K0563103 1.0 ug DNA
EUR 184.8

DBIL4 sgRNA CRISPR Lentivector (Human) (Target 3)

K0563104 1.0 ug DNA
EUR 184.8

Dbil5 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K4706902 1.0 ug DNA
EUR 184.8

Dbil5 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K4706903 1.0 ug DNA
EUR 184.8

Dbil5 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4706904 1.0 ug DNA
EUR 184.8

Dbil5 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV)

LV677401 1.0 ug DNA
EUR 616.8

Dbil5 Lentiviral Vector (Rat) (UbC) (pLenti-GIII-UbC)

LV677405 1.0 ug DNA
EUR 616.8

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)

K6901905 3 x 1.0 ug
EUR 451.2

Mouse Diazepam- binding inhibitor- like 5, Dbil5 ELISA KIT

ELI-46695m 96 Tests
EUR 1038

Mouse Diazepam-binding inhibitor-like 5 (Dbil5)

1-CSB-EP520959MO
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
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  • 50ug
Description: Recombinant Mouse Diazepam-binding inhibitor-like 5(Dbil5) expressed in E.coli

Dbil5 Lentiviral Vector (Rat) (EF1a) (pLenti-GIII-EF1a)

LV677406 1.0 ug DNA
EUR 616.8

Bovine Diazepam- binding inhibitor- like 5, DBIL5 ELISA KIT

ELI-28130b 96 Tests
EUR 1113.6

DBIL5P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV759791 1.0 ug DNA Ask for price

DBIL5P Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV759795 1.0 ug DNA Ask for price

DBIL1 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0562805 3 x 1.0 ug
EUR 451.2

DBIL2 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0562905 3 x 1.0 ug
EUR 451.2

DBIL3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0563005 3 x 1.0 ug
EUR 451.2

DBIL4 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)

K0563105 3 x 1.0 ug
EUR 451.2

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)

K4706905 3 x 1.0 ug
EUR 451.2

DBIL5P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV)

LV759797 1.0 ug DNA Ask for price

DBIL5P2 Lentiviral Vector (Human) (UbC) (pLenti-GIII-UbC)

LV759801 1.0 ug DNA Ask for price

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)

K6901906 1.0 ug DNA
EUR 200.4

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 2)

K6901907 1.0 ug DNA
EUR 200.4

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 3)

K6901908 1.0 ug DNA
EUR 200.4

Rat Diazepam-binding inhibitor-like 5 (DBIL5) ELISA Kit

abx509693-96tests 96 tests
EUR 687.5

DBIL5P Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV759796 1.0 ug DNA Ask for price

DBIL5P2 Lentiviral Vector (Human) (EF1a) (pLenti-GIII-EF1a)

LV759802 1.0 ug DNA Ask for price

DBIL1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0562806 1.0 ug DNA
EUR 200.4

DBIL1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0562807 1.0 ug DNA
EUR 200.4

DBIL1 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0562808 1.0 ug DNA
EUR 200.4

DBIL2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0562906 1.0 ug DNA
EUR 200.4

DBIL2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0562907 1.0 ug DNA
EUR 200.4

DBIL2 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0562908 1.0 ug DNA
EUR 200.4

DBIL3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0563006 1.0 ug DNA
EUR 200.4

DBIL3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0563007 1.0 ug DNA
EUR 200.4

DBIL3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0563008 1.0 ug DNA
EUR 200.4

DBIL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)

K0563106 1.0 ug DNA
EUR 200.4

DBIL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)

K0563107 1.0 ug DNA
EUR 200.4

DBIL4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)

K0563108 1.0 ug DNA
EUR 200.4

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)

K4706906 1.0 ug DNA
EUR 200.4

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)

K4706907 1.0 ug DNA
EUR 200.4

Dbil5 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)

K4706908 1.0 ug DNA
EUR 200.4

Mouse Diazepam-binding inhibitor-like 5 (DBIL5) ELISA Kit

abx509692-96tests 96 tests
EUR 687.5

Dbil5 - Rat, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL710449 5 µg/vial Ask for price

Dbil5 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV677402 1.0 ug DNA
EUR 616.8

Dbil5 - Mouse, 4 unique 29mer shRNA constructs in lentiviral GFP vector

TL519202 5 µg/vial Ask for price

Dbil5 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV677403 1.0 ug DNA
EUR 686.4

Dbil5 Lentiviral Vector (Rat) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV677404 1.0 ug DNA
EUR 686.4

Recombinant Mouse Diazepam-binding inhibitor-like 5 (Dbil5)

CSB-EP520959MO 3601 mg Ask for price

Recombinant Mouse Diazepam-binding inhibitor-like 5(Dbil5)

AP77716 1mg
EUR 2826

DBIL5P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-C-term-HA)

LV759798 1.0 ug DNA Ask for price

DBIL5P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV759793 1.0 ug DNA Ask for price

DBIL5P Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV759794 1.0 ug DNA Ask for price

DBIL5P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-GFP-2A-Puro)

LV759799 1.0 ug DNA Ask for price

DBIL5P2 Lentiviral Vector (Human) (CMV) (pLenti-GIII-CMV-RFP-2A-Puro)

LV759800 1.0 ug DNA Ask for price

Dbil5 - Rat, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR710449 5 µg/vial Ask for price

Dbil5 - Mouse, 4 unique 29mer shRNA constructs in retroviral untagged vector

TR519202 5 µg/vial Ask for price

Dbil5 - Mouse shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL519202V 500 ul each Ask for price

Dbil5 - Rat shRNA lentiviral particles (4 unique 29mer target-specific shRNA, 1 scramble control), 0.5 ml each, >10^7 TU/ml.

TL710449V 500 ul each Ask for price

Direct bilirubin -D-BIL- Colorimetric Assay Kit -Chemical Oxidation Method-

E-BC-K081-M-96T 96T
EUR 150
Description: Quantitative

Direct bilirubin -D-BIL- Colorimetric Assay Kit -Chemical Oxidation Method-

E-BC-K081-M-each each Ask for price
Description: Quantitative

Dbi/ Rat Dbi ELISA Kit

ELI-49488r 96 Tests
EUR 1063.2

Rabbit Anti Human GFAP Monoclonal Clone DBI-7

IRBAHUGFAPDBI7C100UL each
EUR 496
Description: Rabbit Anti Human GFAP Monoclonal Clone DBI-7

DBI

CSB-CL006519HU 10 μg plasmid + 200μl Glycerol Ask for price

DBI

pro-832 5µg
EUR 60
Description: Recombinant Human Diazepam Binding Inhibitor

DBIC

abx283429-100g 100 µg Ask for price

DBIC

abx283429-20g 20 µg
EUR 143.75

DBIC

abx283429-50g 50 µg
EUR 400

DBIBB

562532 1.0mg
EUR 190

DBIBB

C3497-10 10 mg
EUR 271
Description: LPA2 agonist

DBIBB

C3497-5 5 mg
EUR 155
Description: LPA2 agonist

DBIBB

T22070-10mg 10mg Ask for price
Description: DBIBB

DBIBB

T22070-1g 1g Ask for price
Description: DBIBB

DBIBB

T22070-1mg 1mg Ask for price
Description: DBIBB

DBIBB

T22070-50mg 50mg Ask for price
Description: DBIBB

DBIBB

T22070-5mg 5mg Ask for price
Description: DBIBB

DBI siRNA

20-abx913599
  • Ask for price
  • Ask for price
  • 15 nmol
  • 30 nmol

DBI siRNA

20-abx913600
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  • Ask for price
  • 15 nmol
  • 30 nmol

DBI siRNA

20-abx901415
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  • 15 nmol
  • 30 nmol

D-Biotin

04822-04 100MG
EUR 16.8

D-Biotin

04822-91 1G
EUR 66.5

D-Biotin

12987-01 1G
EUR 168

D-Biotin

12987-14 100MG
EUR 56.7

D-Biotin

40200080-1 1 g
EUR 29.57

D-Biotin

40200080-2 5 g
EUR 62.27

D-Biotin

40200080-3 10 g
EUR 99.35

D-Biotin

40200080-4 25 g
EUR 195.74

D-Biotin

5-02219 25g Ask for price

D-Biotin

5-02220 100g Ask for price

DBI ELISA kit

55R-1872 1 kit
EUR 891.6
Description: ELISA kit for the detection of DBI in the research laboratory

D-Biotin

BB0078 1g
EUR 72.53

D-Biotin

B010-1G 1 g
EUR 35.07
Description: C10H16N2O3S

D-Biotin

B010-25G 25 g
EUR 439.34
Description: C10H16N2O3S

D-Biotin

B010-5G 5 g
EUR 123.07
Description: C10H16N2O3S

d-BIOTIN

B140 1G
EUR 187.12

D-Biotin

20-abx082077
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  • Ask for price
  • 1 g
  • 5 g

D-Biotin

abx082331-1g 1 g
EUR 276

D-Biotin

PCT0201-10G 1 unit
EUR 74.93
Description: D-Biotin

D-Biotin

PCT0201-1G 1 unit
EUR 8.33
Description: D-Biotin

D-Biotin

PCT0201-25G 1 unit
EUR 149.74
Description: D-Biotin

D-Biotin

CMS095-10G 1 unit
EUR 69.5
Description: D-Biotin

D-Biotin

CMS095-1G 1 unit
EUR 7.81
Description: D-Biotin

D-Biotin

CMS095-25G 1 unit
EUR 138.85
Description: D-Biotin

D-Biotin

abx082077-100l 100 µl
EUR 137.5

D-Biotin

abx082077-1ml 1 ml Ask for price

D-Biotin

abx082077-200l 200 µl
EUR 187.5

D-Biotin

abx082331-100l 100 µl
EUR 137.5

D-Biotin

abx082331-1ml 1 ml Ask for price

D-Biotin

abx082331-200l 200 µl Ask for price

D-Biotin [BSA]

DAG3281 1mg
EUR 1014

DBI Rabbit pAb

E2513293 100ul
EUR 225
Description: Available in various conjugation types.

DBI Rabbit pAb

E2505370 100ul
EUR 225
Description: Available in various conjugation types.

DBI Rabbit pAb

A13293-100ul 100 ul
EUR 369.6

DBI Rabbit pAb

A13293-200ul 200 ul
EUR 550.8

DBI Rabbit pAb

A13293-20ul 20 ul
EUR 219.6

DBI Rabbit pAb

A13293-50ul 50 ul
EUR 267.6

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