Bibliometrics and Visualization of the Mechanisms of Parkinson’s Diseases based on Animal Models.

Energy metabolism disorder is one of the causes of Parkinson’s disease (PD). Rodents such as rats and mice are often used to establish animal models of PD. This paper uses bibliometric methods to analyze studies of rats and mice models of PD published between 2009 and 2018 in the Web of Science (WOS) database using software CiteSpace V.

In addition, we conducted a literature review on the status of development and research hotspots in this field in 10 articles Related years.The last in mice and rat PD models derived from the database WOS, and keyword analysis in this article is done using CiteSpace V. A timeline graph developed by software to indicate a focus of researchers in total PD field.A of 8636 articles obtained.

The results of cluster analysis in the field of PD such as nerve inflammation, oxidative stress and autophagy contributes to a systematic review of the pathogenesis of PD. At the same time, based on the properties of the drug model, this review has summarized and compared the different administration techniques and mechanisms of 6- hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1, 2, 4, 5 -tetrahydropyridine (MPTP), paraquat and rotenone.According for bibliometric analysis, the study of PD is focused on the mechanism of oxidative stress, neuroinflammation and autophagy.

Activated microglia release inflammatory cytokines; Mitochondrial dysfunction caused by oxidative damage to mitochondrial proteins; normal autophagy-lysosomal pathway can lead to abnormal protein deposition in dopaminergic neurons. In addition, although many animal models of PD have been established, there are some limitations to this model. Therefore, it is necessary to develop models that accurately mimic human PD.

DCTN3 Antibody
1-CSB-PA921442	Cusabio	EUR 317.00 EUR 244.00	100ul 50ul
Description: A polyclonal antibody against DCTN3. Recognizes DCTN3 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:10000, IHC:1:100-1:300

DCTN3 Antibody
36403-100ul	SAB	100ul	EUR 252

DCTN3 siRNA
20-abx913699	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

DCTN3 siRNA
20-abx913700	Abbexa	EUR 551.00 EUR 732.00	15 nmol 30 nmol

DCTN3 Antibody
ABD8351	Lifescience Market	100 ug	EUR 438

DCTN3 Antibody
DF8351	Affbiotech	200ul	EUR 304
Description: DCTN3 Antibody detects endogenous levels of total DCTN3.

anti-DCTN3
YF-PA17547	Abfrontier	50 ul	EUR 363
Description: Mouse polyclonal to DCTN3

anti-DCTN3
YF-PA17548	Abfrontier	50 ug	EUR 363
Description: Mouse polyclonal to DCTN3

DCTN3 Peptide
42-330P	ProSci	0.1 mg	EUR 338
Description: (IN) DCTN3 Peptide

DCTN3 Peptide
42-682P	ProSci	0.1 mg	EUR 338
Description: (IN) DCTN3 Peptide

DCTN3 cloning plasmid
CSB-CL006566HU-10ug	Cusabio	10ug	EUR 233
Description: A cloning plasmid for the DCTN3 gene.

DCTN3 Polyclonal Antibody
A57037	EpiGentek	100 µg	EUR 570.55
Description: The best epigenetics products

Anti-DCTN3 antibody
STJ72399	St John's Laboratory	100 µg	EUR 260

Anti-DCTN3 antibody
STJ72400	St John's Laboratory	100 µg	EUR 359

DCTN3 Conjugated Antibody
C36403	SAB	100ul	EUR 397

DCTN3 Blocking Peptide
DF8351-BP	Affbiotech	1mg	EUR 195

pENTR223-DCTN3 vector
PVT11860	Lifescience Market	2 ug	EUR 304

DCTN3 Antibody, HRP conjugated
1-CSB-PA006566LB01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against DCTN3. Recognizes DCTN3 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

DCTN3 Antibody, FITC conjugated
1-CSB-PA006566LC01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against DCTN3. Recognizes DCTN3 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

DCTN3 Antibody, Biotin conjugated
1-CSB-PA006566LD01HU	Cusabio	EUR 317.00 EUR 335.00	100ug 50ug
Description: A polyclonal antibody against DCTN3. Recognizes DCTN3 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

Mouse DCTN3 shRNA Plasmid
20-abx974349	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

Human DCTN3 shRNA Plasmid
20-abx957717	Abbexa	EUR 801.00 EUR 1121.00	150 µg 300 µg

DCTN3 Recombinant Protein (Mouse)
RP128180	ABM	100 ug	Ask for price

DCTN3 Recombinant Protein (Mouse)
RP128183	ABM	100 ug	Ask for price

DCTN3 Recombinant Protein (Rat)
RP197492	ABM	100 ug	Ask for price

DCTN3 Recombinant Protein (Human)
RP008860	ABM	100 ug	Ask for price

Human Dynactin subunit 3 (DCTN3)
1-CSB-EP006566HU	Cusabio	EUR 380.00 EUR 214.00 EUR 1309.00 EUR 560.00 EUR 873.00 EUR 262.00	100ug 10ug 1MG 200ug 500ug 50ug
Description: Recombinant Human Dynactin subunit 3(DCTN3) expressed in E.coli

Polyclonal DCTN3 Antibody (internal region)
APG00714G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human DCTN3 (internal region). This antibody is tested and proven to work in the following applications:

Polyclonal DCTN3 Antibody (internal region)
APG00715G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human DCTN3 (internal region). This antibody is tested and proven to work in the following applications:

Dynactin Subunit 3 (DCTN3) Antibody
20-abx321092	Abbexa	EUR 439.00 EUR 328.00	100 ul 50 ul

Dynactin Subunit 3 (DCTN3) Antibody
20-abx321093	Abbexa	EUR 439.00 EUR 328.00	100 ul 50 ul

Dynactin Subunit 3 (DCTN3) Antibody
abx149748-100ug	Abbexa	100 ug	EUR 439

DCTN3 Polyclonal Antibody, HRP Conjugated
A57038	EpiGentek	100 µg	EUR 570.55
Description: kits suitable for this type of research

DCTN3 Polyclonal Antibody, FITC Conjugated
A57039	EpiGentek	100 µg	EUR 570.55
Description: fast delivery possible

DCTN3 Polyclonal Antibody, Biotin Conjugated
A57040	EpiGentek	100 µg	EUR 570.55
Description: reagents widely cited

Dynactin Subunit 3 (DCTN3) Antibody
abx431970-200ul	Abbexa	200 ul	EUR 384

Dynactin Subunit 3 (DCTN3) Antibody
abx431971-200ul	Abbexa	200 ul	EUR 286

Dynactin Subunit 3 (DCTN3) Antibody
20-abx210222	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Dynactin Subunit 3 (DCTN3) Antibody
20-abx210223	Abbexa	EUR 411.00 EUR 300.00	100 ul 50 ul

Dynactin Subunit 3 (DCTN3) Antibody
20-abx301171	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Dctn3 ORF Vector (Mouse) (pORF)
ORF042728	ABM	1.0 ug DNA	EUR 506

Dctn3 ORF Vector (Mouse) (pORF)
ORF042729	ABM	1.0 ug DNA	EUR 506

DCTN3 ORF Vector (Human) (pORF)
ORF002954	ABM	1.0 ug DNA	EUR 95

Dctn3 ORF Vector (Rat) (pORF)
ORF065832	ABM	1.0 ug DNA	EUR 506

Human Dynactin 3 (DCTN3)ELISA Kit
201-12-2661	SunredBio	96 tests	EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Dynactin Subunit 3 (DCTN3) Antibody (HRP)
20-abx303590	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Dynactin Subunit 3 (DCTN3) Antibody (FITC)
20-abx303591	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Dynactin Subunit 3 (DCTN3) Antibody (Biotin)
20-abx303592	Abbexa	EUR 411.00 EUR 1845.00 EUR 599.00 EUR 182.00 EUR 300.00	100 ug 1 mg 200 ug 20 ug 50 ug

Human Dynactin 3(DCTN3)ELISA Kit
QY-E03780	Qayee Biotechnology	96T	EUR 361

Dctn3 sgRNA CRISPR Lentivector set (Mouse)
K3108201	ABM	3 x 1.0 ug	EUR 339

DCTN3 sgRNA CRISPR Lentivector set (Human)
K0567401	ABM	3 x 1.0 ug	EUR 339

Dctn3 sgRNA CRISPR Lentivector set (Rat)
K6032901	ABM	3 x 1.0 ug	EUR 339

Mouse Dynactin subunit 3, Dctn3 ELISA KIT
ELI-26362m	Lifescience Market	96 Tests	EUR 865

Bovine Dynactin subunit 3, DCTN3 ELISA KIT
ELI-26525b	Lifescience Market	96 Tests	EUR 928

Dctn3 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3108202	ABM	1.0 ug DNA	EUR 154

Dctn3 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3108203	ABM	1.0 ug DNA	EUR 154

Dctn3 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K3108204	ABM	1.0 ug DNA	EUR 154

Human Dynactin subunit 3, DCTN3 ELISA KIT
ELI-08944h	Lifescience Market	96 Tests	EUR 824

DCTN3 sgRNA CRISPR Lentivector (Human) (Target 1)
K0567402	ABM	1.0 ug DNA	EUR 154

DCTN3 sgRNA CRISPR Lentivector (Human) (Target 2)
K0567403	ABM	1.0 ug DNA	EUR 154

DCTN3 sgRNA CRISPR Lentivector (Human) (Target 3)
K0567404	ABM	1.0 ug DNA	EUR 154

Dctn3 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6032902	ABM	1.0 ug DNA	EUR 154

Dctn3 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6032903	ABM	1.0 ug DNA	EUR 154

Dctn3 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6032904	ABM	1.0 ug DNA	EUR 154

DCTN3 Protein Vector (Human) (pPB-C-His)
PV011813	ABM	500 ng	EUR 329

DCTN3 Protein Vector (Human) (pPB-N-His)
PV011814	ABM	500 ng	EUR 329

DCTN3 Protein Vector (Human) (pPM-C-HA)
PV011815	ABM	500 ng	EUR 329

DCTN3 Protein Vector (Human) (pPM-C-His)
PV011816	ABM	500 ng	EUR 329

DCTN3 Protein Vector (Rat) (pPB-C-His)
PV263326	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Rat) (pPB-N-His)
PV263327	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Rat) (pPM-C-HA)
PV263328	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Rat) (pPM-C-His)
PV263329	ABM	500 ng	EUR 603

Dctn3 3'UTR Luciferase Stable Cell Line
TU104917	ABM	1.0 ml	Ask for price

DCTN3 Protein Vector (Mouse) (pPB-C-His)
PV170910	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPB-N-His)
PV170911	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPM-C-HA)
PV170912	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPM-C-His)
PV170913	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPB-C-His)
PV170914	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPB-N-His)
PV170915	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPM-C-HA)
PV170916	ABM	500 ng	EUR 603

DCTN3 Protein Vector (Mouse) (pPM-C-His)
PV170917	ABM	500 ng	EUR 603

Dctn3 3'UTR GFP Stable Cell Line
TU253211	ABM	1.0 ml	Ask for price

Dctn3 3'UTR Luciferase Stable Cell Line
TU203211	ABM	1.0 ml	Ask for price

DCTN3 3'UTR GFP Stable Cell Line
TU055639	ABM	1.0 ml	EUR 1394

DCTN3 3'UTR Luciferase Stable Cell Line
TU005639	ABM	1.0 ml	EUR 1394

Dctn3 3'UTR GFP Stable Cell Line
TU154917	ABM	1.0 ml	Ask for price

Dctn3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Mouse)
K3108205	ABM	3 x 1.0 ug	EUR 376

DCTN3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K0567405	ABM	3 x 1.0 ug	EUR 376

Dctn3 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
K6032905	ABM	3 x 1.0 ug	EUR 376

Dctn3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 1)
K3108206	ABM	1.0 ug DNA	EUR 167

Dctn3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 2)
K3108207	ABM	1.0 ug DNA	EUR 167

Dctn3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Mouse) (Target 3)
K3108208	ABM	1.0 ug DNA	EUR 167

DCTN3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K0567406	ABM	1.0 ug DNA	EUR 167

DCTN3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K0567407	ABM	1.0 ug DNA	EUR 167

DCTN3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K0567408	ABM	1.0 ug DNA	EUR 167

Dctn3 sgRNA CRISPR/Cas9 All-in-One Lentivector (Rat) (Target 1)
K6032906	ABM	1.0 ug DNA	EUR 167