Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart.

Heart failure stays a significant well being burden around the globe. Despite nice progress in delineation of molecular mechanisms underlying growth of illness, normal remedy has not superior on the similar tempo.

The multifunctional signaling molecule Ca2+/calmodulin-dependent protein kinase II (CaMKII) has acquired appreciable consideration over current years for its central function in maladaptive reworking and arrhythmias in the setting of power illness.

However, these primary science discoveries have but to translate into new therapies for human sufferers. This overview addresses each the promise and boundaries to growing translational therapies that focus on CaMKII signaling to abrogate pathologic reworking in the setting of power illness.

Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart.
Challenges and Opportunities for Therapeutic Targeting of Calmodulin Kinase II in Heart.

Efforts in small molecule design are mentioned, in addition to various focusing on approaches that exploit novel avenues for compound supply and/or genetic approaches to have an effect on cardiac CaMKII signaling. These various methods present hope for overcoming some of the challenges which have restricted the event of new therapies.

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC471049-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC680985-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC681049-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC681049-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC680424-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC680424-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC040985-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC041049-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC681093-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC680028-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC041093-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC940977-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC880028-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC880028-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC470156-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC470156-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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BNC470177-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD50 (ICAM-3)(101-1D2), CF647 conjugate, 0.1mg/mL

BNC470177-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

TGF-beta(1D11.16.8), CF647 conjugate, 0.1mg/mL

BNC470977-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

TGF-beta(1D11.16.8), CF647 conjugate, 0.1mg/mL

BNC470977-500 500uL
EUR 532
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

CD45RA(158-4D3), CF640R conjugate, 0.1mg/mL

BNC400028-100 100uL
EUR 192
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application

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